It depends on two key criteria: shares float and average volume. In some of the low float stocks it could be enough to buy 2k to move the price. That is why the traiding with such stocks could be difficult: the first problem is to create position without influnecing the price, and then another problem would appear: to close position without influnencing the price, especially when you need to get rid of your shares relatively fast. If someone will see the downward movement, he could also sell his shares, creating large movement.
This is one of the reasons why most of the institutional traders avoid such stocks. At the same time, they could provide interesting opporunities for retail traders understanding how it all works.