Surely longer time frames usually equal bigger differences in highs/lows. So stops/targets are likely to be bigger and thus profits/losses are likely to be bigger.
Conversely, larger stops are generally offset by smaller position sizes, so in actual dollar amounts, profits are no bigger. And of course, from a technical perspective my set up might occur 6 times a day on a 1 minute chart, but only 6 times per decade on a weekly chart. (Not that I bother these day with technical set ups)
However, if i did, I know which timeframe I'd rather trade
Then factor in consecutive losses. I think my longest streak has been around 14 trades, which for me was over and done with in a few days. If trading weekly charts I might have had to endure 30 consecutive losing years, which i suspect would be a little more problematic